• Programmatore, analista dati

Research Interests
Social network analysis, machine learning models, pattern matching, graph mining
graph theory, big data analysis,

Professional Experience

2011- to date
“Carlo Besta” Neurological Institute, Milan- Italy
Web: Www.Istituto-Besta.It

Head of Bioinformatics and Senior Data Analyst
Big Data Analytics Research in health care and biological data
Database design and development of clinical and biological data
Principal Investigator (PI) in pharmacogenomics study (Italian Ministry of Health, 2010)

2008- 2011
Genopolis Consortium
University of Milano-Bicocca, Milan, Italy
Web: Www.Genopolis.It
Senior Bioinformatician
Data analyst and reporting of Affymetrix and illumina microarrays
Management and development of AMDA software (**** et al Biotechniques 2013)

2009-2010
Istituto Nazionale dei Tumori, Milan, Italy
Web: Www.Istitutotumori.Mi.It/
Bioinformatics Consultant
Consultant on microarray data analysis

2007-2008
Parco Tecnologico Padano,
Lodi, Italy
Web: Www.Tecnoparco.Org
Data Analyst

Analysis and management of biological data

Key skills
Data Analysis and Management
Expertise in developing analytical pipelines for data analysis and reporting
Project Management and delivery
In-depth knowledge of project management principles and practices with expertise in defining and creating schedules
Strong propensity obtaining results, flexibility, capacity of planning and scheduling, willingness to problem solving

Education
2007
University of Torino, Italy
M.Sc Bioinformatics
Artificial Intelligence

2005
University of Siena, Italy
M.Sc Molecular Biology
Molecular Biology

2003
University of Siena, Italy
B.Sc Biological Sciences
Pharmacology

Computational Skills and Programming
General Programming
R (Development of AMDA Software (Biotechniques 2013), Python, MySQL, Linux Shell
Website Related: SQL, HTML

Software
Graphics: Photoshop, illustrator,
Other: Latex, Work, Excel, Powerpoint

Language Skills

English: Excellent reading, writing and expression skills
Italian: Excellent reading, writing and expression skills

Awards and Honors (Last 2 years)

2015 Travel grant – First Joint Meeting of the Société Francophone du Nerf Périphérique and of the Associazione Italiana per lo studio del Sistema Nervoso Periferico, Paris, France
2014 Travel grant – Associazione Italiana per lo studio del sistem nervoso periferico, Sorrento, Italy
2013 Winner of the best poster price award with title “Evaluation of the epileptogenic zone based on computer assisted network analysis of electrical stimulations during intracranial stereo-EEG recordings”, Society of Neuroscience, San Diego USA
2012 Three-year grant award from the Italian Ministry of Health to a Pharmacogenomics study applied to autoimmune diseases.

Active Funding
Pharmacogenomics research
Project title: A machine-learning approach to pharmacogenomics. Application to therapy of autoimmune diseases, Myastenia Gravis and Multiple Sclerosis
PI: **** ***
Italian Ministery of Health, GR 2010
01/12/2012 – 31/12/2015
€ 283,580,000 (total award; 2 senior researchers)

Peer-reviewed Scientific Papers

[1] S. Marcuzzo, S. Bonanno, D. ****, C. Barzago, P. Cavalcante, S. D’alessandro, R. Mantegazza, P. Bernasconi. “Up-regulation of neural and cell cyscle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage”, Molecular Brain, Jan. 2015

[2] C. Cappelletti, B. Galbardi, D. ****, G. Vattemi, V. Guglielmi, P. Tonin, F. Salerno, L. Morandi, G. Tomelleri, R. Mantegazza, and P. Bernasconi, “Autophagy, inflammation and innate immunity in inflammatory myopathies.,” PLoS One, vol. 9, no. 11, p. e111490, Jan. 2014.
[3] Maggi L, Amico AD, Pini A, Sivo S, Ambrosio PD, Sala S et al. The Italian experience in a large cohort of patients. Neurology, Oct. 2014

[4] R. Brugnoni, D. ****, P. Imbrici, M. Pessia, E. Canioni, L. Colleoni, N. K. de Rosbo, L. Morandi, P. Cudia, N. Gashemi, P. Bernasconi, J.-F. Desaphy, D. Conte, and R. Mantegazza, “A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene” J. Hum. Genet., vol. 58, pp. 581–7, 2013.
[5] S. Marcuzzo, D. ****, R. Mantegazza, F.Baggi, S.Bonanno, C. Barzago, P. Cavalcante, N.K. de Rosbo, P. Bernasconi, “Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells.” Experimental Neurology, volume 252, pp 91-101
[6] R. Brugnoni, D. ****, P. Imbrici, M. Pessia, E. Canioni, L. Colleoni, N. K. de Rosbo, L. Morandi, P. Cudia, N. Gashemi, P. Bernasconi, J.-F. Desaphy, D. Conte, and R. Mantegazza, “A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene.,” J. Hum. Genet., vol. 58, pp. 581–7, 2013.
[7] J.-D. Docquier, M. Benvenuti, V. Calderone, F. Giuliani, D. ****, F. De Luca, G. M. Rossolini, and S. Mangani, “Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates.,” Antimicrob. Agents Chemother., vol. 54, pp. 2167–2174, 2010.
[8] F. Orzan, S. Pellegatta, P. L. Poliani, F. Pisati, V. Caldera, F. Menghi, D. ****, C. Marras, D. Schiffer, and G. Finocchiaro, “Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.,” Neuropathol. Appl. Neurobiol., vol. 37, pp. 381–394, 2011.
[9] C. G. Faber, G. Lauria, I. S. J. Merkies, X. Cheng, C. Han, H.-S. Ahn, A.-K. Persson, J. G. J. Hoeijmakers, M. M. Gerrits, T. Pierro, R. Lombardi, D. ****, S. D. Dib-Hajj, and S. G. Waxman, “Gain-of-function Nav1.8 mutations in painful neuropathy,” Proceedings of the National Academy of Sciences. 2012.
[10] L. Colleoni, D. ****, L. Maggi, G. Camera, E. Canioni, P. Cavalcante, N. Kerlero de Rosbo, F. Baggi, C. Antozzi, P. Confalonieri, R. Mantegazza, and P. Bernasconi, “A New Thiopurine S-Methyltransferase Haplotype Associated With Intolerance to Azathioprine,” The Journal of Clinical Pharmacology. 2012.
[11] M. C. Speranza, V. Frattini, F. Pisati, D. ****, P. Porrati, M. Eoli, S. Pellegatta, and G. Finocchiaro, “NEDD9 , a novel target of miR-145 , increases the invasiveness of glioblastoma,” Oncotarget, vol. 3, p. 723E–734, 2012.
[12] G. Povero, E. Loreti, C. Pucciariello, A. Santaniello, D. Di Tommaso, G. Di Tommaso, D. ****, F. Zolezzi, A. Piaggesi, and P. Perata, “Transcript profiling of chitosan-treated Arabidopsis seedlings.,” J. Plant Res., vol. 124, pp. 619–629, 2011.
[13] D. ****, F. Clarelli, F. Vitulli, N. K. de Rosbo, O. Beretta, M. Foti, P. Ricciardi-Castagnoli, and F. Zolezzi, “AMDA 2.13: A major update for automated cross-platform microarray data analysis.,” Biotechniques, vol. 53, pp. 33–40, 2012.
[14] V. Frattini, F. Pisati, M. C. Speranza, P. Luigi, G. Frigé, G. Cantini, D. ****, and M. Cominelli, “FOXP3 , a novel glioblastoma proliferation and migration affects proliferation and migration,” Oncotarget, vol. 3, pp. 1146–1157, 2012.
[15] R. Spiering, R. van der Zee, J. Wagenaar, D. ****, F. Zolezzi, W. van Eden, and F. Broere, “Tolerogenic Dendritic Cells That Inhibit Autoimmune Arthritis Can Be Induced by a Combination of Carvacrol and Thermal Stress,” PLoS ONE, vol. 7. p. e46336, 2012.
[16] C. G. Elsik, et al. “The genome sequence of taurine cattle: a window to ruminant biology and evolution” Science, vol. 324, pp. 522–528, 2009.

Invited talks (Last 2 years)

Year
Title and Place
Contribution/Participation

2015
SFNP and ASNP joint Meeting, Paris, France
Oral presentation

2014
Associazione Italiana del Sistema Nervoso Periferico (ASNP), Sorrento, Italy
Oral presentation

2013
NGS & Bioinformatics Summit, Berlin, Germany
Hand-on data analysis training on Next Generation Sequencing

2013
Società Italiana di Neurologia (SIN), Milan, Italy
Oral Presentation

2013
Italian Society of Neuroscience (SINS) Rome, Italy
Poster Presentation

2013
Up Close and Personalized, Paris, France
Oral Presentation

Professional service
Reviewer (journals): Neurological Science
Web: http://www.springer.com/medicine/neurology/journal/10072

References
Nicole Kerlero de Rosbo, PhD, Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Largo Daneo 3, 16132 – Genoa, Italy, nicole.kerleroderosbo@unige.it
Francesca Zolezzi, Principal Investigator, Functional Genomics, Singapore Immunology Network (SIgN), Biomedical Sciences Institutes (BMSI), 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, francesca_zolezzi@immunol.a-star.edu.sg

Miscellaneous
Publication Records
H-index: 7 (Google Scholar)
i10-Index: 7 (Google Scholar)
Web: http://scholar.google.it/citations?user=Z76JpUMAAAAJ&hl=it

Milan, 1 March 2015

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